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Therapeutic vaccine candidates utilizing viral vectors encoding LMP2 have effectively induced virus-certain CD8⁺ T mobile responses in early-stage clinical trials. Furthermore, adoptive T mobile therapies like posoleucel also target LMP2 together with other latency proteins for example EBNA1, reinforcing its significance being a conserved and immunodominant antigen.
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EBNA-3a seems to deal with a subset of mobile genes, many of which overlap with Gentlemen and women controlled by EBNA2. The 2 proteins can act antagonistically or cooperatively to regulate gene expression.
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